Board the ultra-luxurious Crystal Serenity in Athens for this voyage from Greece to Italy, calling at Turkey and Malta, too.
We head south to enchanting Santorini, with its white cube dwellings clinging to the edge of a sunken volcano, then north-east to the cosmopolitan seaside resort of Bodrum for a taste of the Turkish high life.
A day at sea heading west brings us first to Valletta, Malta’s capital, then Tripani in Sicily. Discover how the strategic location of both these enchanting cities has turned them into fascinating cultural crossroads.
Cagliari introduces us to another Italian island, Sardinia, with a mix of medieval mystery and gorgeous beaches to explore.
Onwards we go to our final destination, Civitavecchia, and the promise of some time in Rome.
Ports of Call:
- Day 1: Athens, Greece
- Day 2: Santorini, Greece
- Day 3: Bodrum, Turkey
- Day 4: Day at Sea
- Day 5: Valletta, Malta
- Day 6: Trapani, Italy
- Day 7: Cagliari (Sardinia), Italy
- Day 8: Civitavecchia (Rome), Italy
For more info, please contact Virtuoso Advisor, Marie Hodges at (847) 519-4781 or marieh@travelexinternational.com.
Mediterranean Crystal Cruise Itinerary
Day 1: September 15, 2026 – Piraeus (Athens), Greece – DEPARTURE 7:00PM
Experience the vibrant and historic port of Piraeus, Athens gateway to the Aegean islands and beyond, and find a rich maritime heritage, a bustling local culture, and access to the wonders of Athens. Venture through Greece’s largest port city, Piraeus, as you make your way to the cradle of Western culture and the birthplace of democracy. Athens, among the world’s oldest cities with a history spanning 3,400 years, has long been the location of myth and muse, and its ancient heritage is still an incredible source of inspiration. Here, the Acropolis crowns the city as home to the Parthenon and other legendary temples and monuments.
Day 2: September 16, 2026 – Santorini, Greece – (8:00AM – 6:00PM) – ANCHOR
Santorini is a breathtaking island in the southern Aegean Sea known for its iconic blue-domed churches, picturesque whitewashed buildings, and stunning sunsets. Of all the Cyclades Islands, Santorini is often considered the most dramatic with its dark landscape and iconic whitewashed buildings. The rich soil is ideal for grapes and local vines produce a cherished crop known for its special volcanic taste. Picturesque Thira, or Fira Town, laid out along the edge of a cliff at the rim of the now extinct caldera, exudes an easy charm.
Day 3: September 17, 2026 – Bodrum, Turkey – (8:00AM – 6:00PM)
Today, its Old Town is alive with contemporary shops and traditional bazaars that teem with locals and visitors, surrounded by lively cafés. But this charming “old” quarter is infantile compared to one of Bodrum’s most important sites: the Mausoleum of Halicarnassus. Dating back to 350 B.C., the 140-foot white marble structure still captivates even the savviest scientists, ranking as one of the Seven Wonders of the Ancient World.
Day 4: September 18, 2026 – Day at Sea
Day 5: September 19, 2026 – Valletta, Malta (8:00AM – 6:00PM)
Discover the capital city of Malta, a vibrant Mediterranean hub home to stunning baroque architecture and ancient ruins. Beautiful and unique, known for the sun-kissed, sand-colored buildings that populate its walled streets. Discover important landmarks such as St. John’s Co-Cathedral, the National Museum of Archeology or the Lower Barrakka Gardens as you stroll.
Day 6: September 20, 2026 – Trapani, Italy (8:00AM – 5:00PM)
There is no shortage of beautiful, historical places in Sicily, but Trapani, on the island’s west coast, seems to have it all.Once the port for the Elymian settlement of Eryx, the city became a Carthaginian naval base in 260 BCE before the Romans took it over in 241 BCE. It thrived through the Middle Ages, and much of the medieval old city remains intact. Discover the historic center with its narrow alleys, small shops, and cozy trattorias. Once you’ve worked up an appetite, find a shady terrace and sample the morning-fresh seafood washed down with a glass of local Marsala wine. The area is one of the most important coastal wetlands, providing sanctuary to many migratory birds. Head to the salt flats at the Riserva Naturale Saline di Trapani e Paceco, just three miles from the port, where white pyramids of salt and pink flamingos create a colorful, striking scene.Of course, no trip to Sicily would be complete without a dip in the sea; surrounded by turquoise waters, pristine sands, and rugged coastline, Trapani’s beaches are a delight for sun worshipers.
Day 7: September 21, 2026 – Cagliari (Sardinia), Italy (7:00AM – 4:00PM)
Cagliari, capital of Sardinia, sprawls across the hills promising awe-inspiring views for those who venture to Monte Urpinu Park. At its heart lies the historic Castello district, where a Roman amphitheater, medieval towers built by the Pisans, and a 13th-century cathedral with an intricately carved crypt sit beside the monolithic architecture of the Mussolini era. Down by the harbor, the eateries and bars in the Marina buzz with life. In Via Sardegna and Via Cavour taste local flavors such as the peppery salami mustela, salty pecorino cheese, and carta musica, a wafer-thin flatbread said to sound like music when it snaps. They all go well with a glass of cannonau or vernaccia, the island’s robust wines.
Day 8: September 22, 2026 – Civitavecchia (Rome), Italy
Discover the charming port town of Civitavecchia, the gateway to Rome and the treasures of the Eternal City. Venture through Civitavecchia, noted for its fine seafood and beautiful monuments. Then, travel to Rome, with more than 2,500 years of history and ancient landmarks that will leave you with memories for a lifetime.

